Illumina Inc. (ILMN)
Executive Summary Investment Thesis: Illumina pioneered DNA sequencing and commands 80%+ market share in next-generation sequencing (NGS). The company possesses formidable moats from network effects (largest installed base) and switching costs (labs built around Illumina platforms). However, the catastrophic GRAIL acquisition ($7.1B writeoff), three consecutive years of losses, equity collapse from $10.8B to $2.4B (-78%), and management turmoil create massive uncertainty. Trading at $120 (down 75% from $450 peak), this is either a value trap or maximum pessimism opportunity—contingent entirely on operational turnaround execution. ...